By Nozomu Mori, Inhee Mook-Jung
This e-book brings jointly the main updated details on fresh study result of top laboratories on getting older technological know-how in East Asia, rather in Japan, Korea, and Hong Kong. beginning with a accomplished evaluation of assorted hypotheses on organic mechanisms of getting older by way of Dr. Sataro Goto, every one bankruptcy covers large features of the latest findings in aging-related themes: centenarian reports and genome research of progeria, metabolic biochemistry and neurobiology, sturdiness controls in yeast and nematodes, oxidative tension and calorie limit, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with additional power healing techniques to those age-related neurodegenerative illnesses. additionally incorporated, partly, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older middle for sturdiness (AACL) that has been held each year alternating among Japan and Korea over the last decade. This e-book can function an invaluable source for locating acceptable collaborators within the parts it covers. the objective readership is made from graduate scholars and researchers at universities, clinical and/or life-science colleges, and biomedical and pharmaceutical institutes.
Why does getting older exist? How will we age? How is every one organism’s lifespan decided? those are primary questions within the box. We can be nonetheless faraway from reaching a whole view of getting older mechanisms, yet this ebook, Aging Mechanisms, deals a good chance to familiarize yourself with the main up to date development within the biomedical learn of getting older in Japan and Korea, the 2 top international locations for human longevity.
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Additional info for Aging Mechanisms: Longevity, Metabolism, and Brain Aging
2007). 9 % of an estimated 1,785 centenarians living in this area during the study period. 0 %) individuals agreed to participate in mailed survey. 5 % of the recruiting letter recipients) participated in the visit survey for medical examination. 7 % of the letter recipients) participated in a mail survey without a visit by study staff. 9–1). 3 %) lived alone. A geriatrician, a psychologist, and a nurse performed the medical, cognitive and psychological evaluations and phlebotomy. After completing a medical examination and providing a blood sample, the psychologist conducted a cognitive assessment and psychological test battery.
These findings are compatible with the dysdifferentiation theory of aging (Somel et al. 2006). This theory has never been popular, but has been recently revived as the epigenetic theory of aging. Epigenetics is a phenomenon in which a fixed pattern of gene expression in a cell or an organism is inherited from one generation to the next without any changes in the genomic nucleotide sequence. This definition has been broadened to include the long-term stable control of gene expression in differentiated cells without changes in the nucleotide sequence, as manifested in various physiological and pathological situations, including aging and age-related diseases.
Exp Gerontol 10:119–136 Ono T, Cutler RG (1978) Age-dependent relaxation of gene repression: increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice. Proc Natl Acad Sci U S A 75:4431–4435 Orgel LE (1963) The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc Natl Acad Sci U S A 49:517–521 26 S. Goto Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC et al (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice.