By Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

content material: Innervation of Senile Plaques: A hyperlink among Amyloid and Neurofibrillary Pathology? B. Delatour, V. Blanchard, L. Pradier, and C. Duyckaerts Vascular elements and Alzheimer's illness, I. Skoog, D. Gustafson, and M. Sjogren The position of White topic Lesions in Dementia, L. Pantoni Subclassification of gentle Cognitive Impairment in study and medical perform, S. Gauthier and J. Touchon Neuropsychiatric features of gentle Cognitive Impairment, T.J. Hung and J.L. Cummings Cognitive Rehabilitation in gentle Cognitive Impairment and Prodromal Alzheimer's ailment, M. van der Linden, A.-C. Juillerat, and X. Delbeuck scientific Trial layout within the Age of Dementia remedies: demanding situations and possibilities, E. Mohr, C.L. Barclay, R. Anderson, and J. consistent Ethics of study in Dementia, J. Karlawish Memantine: A Glutamate Antagonist for remedy of Alzheimer's illness, R. Smith Doody, B. Winbald, and V. Jelic administration of Comorbidity in Alzheimer's ailment, R. Jones dietary Prevention in Alzheimer's sickness, O. Guerin and B. Vellas Index

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Simons M, Keller P, De Strooper B et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998; 95:6460–6464. 42 VASCULAR FACTORS AND ALZHEIMER’S DISEASE 120. Fassbender K, Simons M, Bergmann C et al. Simvastatin strongly reduces levels of Alzheimer’s disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 2001; 10:10. 121. Refolo LM, Malester B, LaFrancois J et al. Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model.

Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN). Stroke 1996; 27:30–36. Amar K, Wilcock G, Scott M. The diagnosis of vascular dementia in the light of the new criteria. Age Ageing 1996; 25:51–55. Ferrucci L, Guralnik J, Salive M et al. Cognitive impairment and risk of stroke in the older population. J Am Geriatr Soc 1996; 44:237–241. Gale C, Martyn C, Cooper C. Cognitive impairment and mortality in a cohort of elderly people. BMJ 1996; 312:608–611.

Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of cholesterol. Neurosci Lett 1995; 187:142–144. Simons M, Keller P, De Strooper B et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998; 95:6460–6464. 42 VASCULAR FACTORS AND ALZHEIMER’S DISEASE 120. Fassbender K, Simons M, Bergmann C et al. Simvastatin strongly reduces levels of Alzheimer’s disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

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