By J Tramper; et al

The overseas symposium ''Fundamentals of Biocatalysis in Non-Conventional Media'' used to be equipped less than auspices of the operating get together utilized Biocatalysis of the ecu Federation of Biotechnology. one of the issues mentioned on the symposium have been physical-chemical points equivalent to pH, water-activity, viscosity, dielectric constants, polarity and so on. on the subject of biocatalysis in non-conventional media. New measuring strategies have been brought. for individuals operating within the box of biocatalysis in non-conventional media this publication will supply a very good evaluation of the achieve in figuring out over the past 5 years of the elemental facets of biocatalysis in non-conventional media

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G o e t s c h e l , R. & B a r , R. ( 1 9 9 1 ) . Enzyme Microb. Technol. 1 3 , 2 4 5 - 2 5 1 . D. D. ( 1 9 8 8 ) . Enzyme Microb. Technol. 10, 6 6 9 - 6 7 4 . J. & Troy, F . A . ( 1 9 8 9 ) . Chem. Phys. L i p i d s 5 1 , 2 0 5 - 2 1 2 . L a B e l l a , F . S . ( 1 9 8 1 ) . Can. J . P h y s i o l . Pharmacol. 5 9 , 4 3 2 - 4 4 2 . Osborne, S . J . , Leaver, J . K. & Dunnill, P. ( 1 9 9 0 ) . Enzyme Microb. Technol. 12, 2 8 1 - 2 9 1 . Samanta, T . B . K. ( 1 9 8 7 ) . J . S t e r o i d Biochem.

These molecules are competitive inhibitors [8] and a direct relation can be obtained between their protective effect and their inhibition constant (Table 1). The more important the affinity for the active site of the enzyme, the stronger is the protective effect of the molecule. These additives have to be at very high concentration to have a marked interaction with the active site of the enzyme. Then, these results show that the interaction of the polyols and the sugars with the active site of the enzyme is only one of the factors of the enzyme stabilization mechanism.

Arthur, R . , C h a f e t z , R . , & Martin, D. ( 1 9 9 0 ) . Anesth. Analg. 7 1 , 1 5 8 - 1 7 0 . Yguerabide, J . & Yguerabide, E . E . ( 1 9 8 5 ) . In "Enzymes of B i o l o g i c a l Membranes" 2nd. ed. N. e d . ) v o l . 1 , 3 9 3 - 4 2 0 , Biocatalysis in Non-Conventional Media, edited by J. Tramper et al. V. All rights reserved. 37 A comparison of enzymatic reactions in aqueous, organic and multiphase systems T. Scheper» U. Bornscheuer, A. Capewell, A. G. 3,3000 Hannover 1, Germany Η· Meyer Institut für Organische Chemie, Schneiderberg 1B, 3 0 0 0 Hannover 1, Germany F .

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