By Peter H. Seeberger, Christoph Rademacher

Medicinal chemistry is either technology and artwork. The technology of medicinal chemistry deals mankind one among its most sensible hopes for making improvements to the standard of existence. The artwork of medicinal chemistry keeps to problem its practitioners with the necessity for either instinct and adventure to find new medicinal drugs. for that reason sharing the event of drug examine is uniquely helpful to the sphere of medicinal chemistry. Drug examine calls for interdisciplinary team-work on the interface among chemistry, biology and drugs. for that reason, the topic-related sequence themes in Medicinal Chemistry covers all appropriate points of drug study, e.g. pathobiochemistry of illnesses, id and validation of (emerging) drug objectives, structural biology, drugability of pursuits, drug layout techniques, chemogenomics, artificial chemistry together with combinatorial equipment, bioorganic chemistry, ordinary compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions at the molecular point, structure-activity relationships, drug absorption, distribution, metabolism, removing, toxicology and pharmacogenomics. commonly, certain volumes are edited by means of renowned visitor editors.

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The small size and high electronegativity of fluorine are among properties of this element that lend special advantages such as blood brain barrier penetration. Fluorinated analogues of 21 may greatly improve the therapeutic potential without Iminosugars: Therapeutic Applications and Synthetic Considerations 43 compromising the chaperoning capacity. Bioavailability, CNS penetration and clearance are all enhanced and may result in associated improvements in CNS glucocerebrosidase enhancement and enhanced therapies for both Gaucher disease and Parkinson’s disease in Gaucher gene carriers.

35 37 37 38 43 43 1 Introduction The importance of nucleic acids and proteins in providing biochemical targets in the search for new drugs is well established and has been successfully exploited over many years leading to many marketed drugs. However, these biopolymers do not account for the development, function and dysfunction of pathways, cells, tissues and biological systems alone. Carbohydrates comprise another major molecular class incorporating wide structural diversity that underlies a vast array of biological function [1–15].

Primarily this has been a consequence of the compound class consisting of stereochemically complex scaffolds of a highly polar nature. However, with an appropriate synthetic strategy and sagacious use of starting materials these problems can and have been overcome. This has been possible through an increasing array of affordable chiral pool molecules becoming available and significant advances in analytical methodology. Synthetic access, purification and high cost of goods are no longer sufficient reasons to avoid iminosugars.

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