By Martine Extermann MD, Lodovico Balducci, William B. Ershler, Gary H. Lyman, Martine Extermann

The prevention and therapy of melanoma in older sufferers calls for an individualized technique, as age motives unpredictable effects from sufferer to sufferer. thoroughly revised and up to date, this moment variation of a bestseller allows clinicians to decide on the very best melanoma care. Highlighting rising concerns in geriatric oncology, it is helping physicians advertise melanoma prevention and exhaustively experiences the biology of melanoma and getting older, epidemiologic tendencies, and scientific trials. New chapters comprise fabric on themes comparable to overview, fragility, symptom administration, and emergencies, and reports of the effectiveness of teaching courses in geriatric oncology.

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Proc Am Soc Clin Oncol 2000; 19:241a (Abst 933). 19. Cohen HJ, Cox E, Manton K, Woodbury M. Malignant melanoma in the elderly. J Clin Oncol 1987; 5:100–6. 20. Boffeta P, Parkin DM. Cancer in developing countries. CA Cancer J Clin 1994; 44:81–90. 21. Schiffer CA, Mclntyre OR. Age related changes in adults with acute leukemia. In: The Underlying Molecular, Cellular. and Immunological Factors in Cancer and Aging (Yang SS, Warner HR, eds). New York: Plenum Press, 1993:215–29. 22. Balducci L, Yates J.

Ann Intern Med 1973; 78:127–30. 30. Kennedy BJ. The origin and evolution of Medical Oncology. Lancet 1999; 354(Suppl): 41. Aging and cancer 17 31. Kennedy BJ. Aging and cancer. Oncology 2000; 14:1731–40. 1 Medical knowledge may be derived from personal experience as well as systematic research. Our knowledge base represents an enormous collection of facts as well as opinion gathered over years of formal education, training, and experience in both preclinical and clinical settings. On the other hand, our understanding of how to gather information and evaluate it in order to arrive at correct decisions is obtained in a much less direct manner, largely through observation of experienced clinicians and trial and error.

The higher rates of cure of acute leukemia in children, testicular cancer in men, and Hodgkin lymphoma are responsible for a 23% decrease in cancer mortality in persons under 55 years. 5 US cancer mortality per 10000014 Year Age <55 >55 1968 43 775 1985 35 905 −23% +17% % change Physiology of aging The normal process of aging is associated with a progressive age-related reduction in function of many organs, including losses such as renal, pulmonary, immune, cardiac, hematologic, hepatic, muscle, sight, hearing, osseous, and brain functions.

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