By Kazuhiro Kohama, Hiroshi Maruta

Книга G Proteins, Cytoskeleton and melanoma G Proteins, Cytoskeleton and CancerКниги Медицина Автор: Hiroshi, Ed. Maruta Год издания: 1998 Формат: pdf Издат.:LANDES BIOSCIENCE PUBLISHERS Страниц: four hundred Размер: 3,3 Mb ISBN: 1570595518 Язык: Английский0 (голосов: zero) Оценка:This publication is ready the position of G protein-mediated sign transduction--Ras, Rho, gelsolin, et cetera--and the cytoskeleton in carcinogenesis.

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Cooper JA. The role of actin polymerization in cell motility. Annu Rev Physiol 1991; 53:585-605. 26. Carlsson L, Nystrom LE, Sundkvist I, Markey F, Lindberg U. Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J Mol Biol 1977; 115:465-483. 27. Schutt CE, Myslick JC, Rozycki MD, Goonesekere NCW, Lindberg U. The structure or crystalline profilin-∀-actin. Nature 1993; 365:810-816. 28. Cedergren-Zeppezauer ES, Goonesekere NCW, Rozycki MD et al. Crystallization and Structure Determination of Bovine Profilin at 2,0 A° Resolution.

Interaction of thymosin beta 4 with muscle and platelet actin: Implications for actin sequestration in resting platelets. Biochemistry 1992; 31:6179-6185. 41. Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL. Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J Biol Chem 1993; 268:502-509. 42. Carlier MF, Pantaloni D. Actin assembly in response to extracellular signals: role of capping proteins, thymosin beta 4 and profilin. Semin Cell Biol 1994; 5:183-191.

In contrast to the T∀4-actin complex, the profilin-actin complex is able to associate productively to the barbed ends, but not to the pointed end. As a result, profilin behaves as a bona fide G-actin sequestering protein when barbed ends are capped, but exhibits a different, opposite behavior when barbed ends are uncapped. 35,42 This happens because in the presence of profilin, both G-actin and profilin-actin can undergo the monomer-polymer exchange reactions at the barbed end which maintain the stability of the filament; the contribution of profilin-actin in this maintenance of steady state reduces the contribution of actin.

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