By P. Michael Conn

The Handbook of versions for Human getting older is designed because the purely entire paintings to be had that covers the variety of getting older versions at present on hand. for every animal version, it offers key features of biology, nutrients, components affecting existence span, equipment of age decision, use in learn, and disadvantages/advantes of use. Chapters on comparative versions take a huge sweep of age-related ailments, from Alzheimer's to joint sickness, cataracts, melanoma, and weight problems. moreover, there's an old evaluation and dialogue of version availability, key tools, and moral issues.

  • Utilizes a multidisciplinary approach
  • Shows methods and methods no longer on hand in basic publications
  • First quantity of its style to mix either tools of research for human getting older and animal models
  • Over 2 hundred illustrations

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Comparisons among differentially aging mice at relatively early ages also have the benefits of being faster, less expensive, and less confounded by disease and survivor effects than experiments which require data from aged organisms. Principle #10: Avoid using Laboratory Rodents for Studies of Aging Or, to be more diplomatic about it, avoid using only laboratory rodents for studies of aging. This principle has two subcomponents: (a) an argument that laboratoryadopted rodent stocks are a particularly poor choice on which to develop general ideas about aging, and (b) the more important point that important insights into mammalian aging are likely to require data on species that age at different rates.

In my own laboratory we prefer to evaluate animals at ages where 90% or more of the population is still alive, and we almost never make experimental use of mice older than the age of median survival. 1 3 1 > 10 Principle #2: Don't Use Mice that are too Young, Either 15 20 Age (months) The goal of this precept is to avoid confusing developmental changes with the effects of aging. Although it takes a mere 8 weeks or so for mice to become reproductively competent, many physiological systems and body dimensions continue to change along developmental trajectories that can, in poorly designed studies, be confused with aging.

This makes good sense when the cost of each test is the same, but in a typical aging experiment the cost of obtaining and testing an elderly mouse may be a good deal higher than the cost for a young control. 1, for example, the production cost of a 25-month-old mouse, under plausible assumptions, may be 10-fold the cost of a 5-month-old mouse. Unbalanced designs, in which groups are permitted to have different numbers of subjects, can minimize the cost of the experimental protocol by using more mice of the less expensive variety.

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