By Riki Kurokawa
This ebook offers a typical precept of activities of lengthy noncoding RNAs (lncRNAs) from issues of view on the atomic, molecular and mobile degrees. on the atomic point, chemical reviews of ribonucleic acids clarify the chemical habit of lncRNAs. Structural organic research of lncRNAs and its binding proteins additionally demonstrate the perfect mechanisms in their activities. Molecular organic ways bring about insights into molecular mechanisms of those lncRNA activities. on the mobile or person point of research, we snatch the biology and medication of lncRNAs. those 3 layers of methods are completely new and convey novel insights into capabilities of lncRNAs in dwelling cells. The e-book contains 5 elements: 1) Bioinformatics and different methodologies for lncRNAs, 2) Atomic and molecular buildings of lncRNAs, three) Molecular services of lncRNAs, four) organic activities of lncRNAs, and five) capability results for medical medication. those sections attach good and paintings synergistically. The publication is for researchers whose forte is RNA biology and chemistry and in addition for complicated scholars on the graduate and undergraduate degrees. Readers can clutch the vanguard of lncRNA stories in a entire demeanour and are encouraged to pursue their very own specific interests.
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Extra info for Long Noncoding RNAs: Structures and Functions
The identified compounds selectively inhibited miRNAs, and the designer small molecules targeting the precursors of the miRNAs (miR-96, miR-182, miR-183, and miR-210) also had significant bioactivity (Fig. 6b). In addition, the miR-96-targeting lead compound effectively modulated the miR-96-FoxO1 regulation pathway with high selectivity and induced apoptosis. Programmable DNA-binding synthetic small molecules called PIPs artificially modulate gene expression in living cells in a sequence-specific manner by binding to the minor groove of DNA by following a unique DNA-binding rule.
Appl Immunohistochem Mol Morphol 18:532–545 Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008) A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS One 3:e1486 Kilburn D, Roh JH, Guo L, Briber RM, Woodson SA (2010) Molecular crowding stabilizes folded RNA structure by the excluded volume effect. J Am Chem Soc 132:8690–8696 Kladwang W, Mann TH, Becka A, Tian S, Kim H, Yoon S, Das R (2014) Standardization of RNA chemical mapping experiments.
2010; Novikova et al. 2012). Among the wide spectrum of chemical reagents, base-specific DMS is frequently used to study intact cells (Wells et al. 2000). Two electrophilic SHAPE reagents, FAI (2-methyl-3-furoic acid imidazolide) and NAI (2-methylnicotinic acid imidazolide), with extended half-lives and better solubility, gave consistent results in determining 5S rRNA in different cell lines and modified nuclear RNAs (SNORD3A) and U2 RNA (Spitale et al. 2013). Therefore, these reagents could be used in the future for investigating nuclear-retained transcripts.