By John Wilson

The issues publication goals to supply a operating remark for Molecular Biology of the mobile, 5th version by means of Alberts et al. As we wrote in past prefaces, we want to stimulate our readers to invite questions in addition to to just accept, digest, and examine the tales that «the huge publication» tells. In actual existence, despite the fact that, wisdom and figuring out come from learn, which involves interest, puzzlement, doubt, feedback, and debate.

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Extra resources for Molecular Biology of the Cell. The Problems Book

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38 x w- 1 6 g cm 2 / K sec2 , T = temperature in K (3rC is 3 1 0 K) , m mass in g / molecule. Calculate the instantaneous velocity of a water molecule (molecular mass = 18 daltons) , a glucose molecule (molecular mass = 1 80 daltons) , and a myo ­ globin molecule (molecular mass = 1 5,000 daltons) at 37°C. Just for fun, con­ vert these numbers into kilometers / hour. Before you do any calculations, you might try to guess whether the molecules are moving at a slow crawl ( < l km / hr) , an easy walk ( 5 km / hr) , o r a record-setting sprint (40 km / hr) .

I n the c o nversion o f 3PG to PEP (the first two reactions i n Figu re 2-3 2 ) , a low- energy p h o s phate bond is turned into a high-en ergy phosp h ate b o n d . �) fo r hydrolysis of the p h o s ­ p h ate group in 3 P G is about -3 . 3 kcal ! mole, whereas hydrolysis o f t h e p h o s ­ p h a t e gro up i n P E P (converting i t to pyruvate) h a s a t. � of - 1 4 . 8 kcal / m o l e . 4 kcal / m ole, can h ave such an e n o r m o u s effect o n the free energy for the subsequ e n t hydro lys i s of the phosphate b o n d ?

How many mL of KOH were added to neutralize all of the protons derived from HCl or acetic acid? The p oint at which neutralization occurs is termed the equivalence point. B. For each solution estimate the pH at the equivalence point. C. Estimate the p K for acetic acid. 2-53 The Henderson-Hasselbalch equation pH = pK + log [A-) [HA) is a useful transformation of the equation for dissociation of a weak acid, HA: [H+][A-) K - [HA) A. It is instructive to use the Henderson-Hasselbalch equation to determine the extent of dissociation of an acid at pH values above and below the pK For the p H values listed in Table 2-3, fill in the values for log [A-) I [HA) and [A-) I [HA), and indicate the percentage of the acid that has dissociated.

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