By Charlotte Auerbach

This e-book is meant for the senior undergraduate (Honours pupil) in genetics, and for the postgraduate who desires a survey of the total box or details on a different sector inside of it. that allows you to cater for readers with such diverse necessities, i've got made the checklist of references strangely huge for a textbook. It comprises classical papers in addition to very fresh ones (to the top of 1974); reports in addition to really good articles; undemanding expositions from clinical American in addition to hugely technical papers from journals on genetics and molecular biology. In components of lively examine, i've got given choice to the newest references, with the intention to lead the reader to prior ones. as well as the references on the finish of every bankruptcy, a bibliography on the finish of the publication lists appropriate books and normal studies. except the 1st bankruptcy, the e-book isn't written as a background of mutation examine; yet all through i've got attempted to stress the continuity of the issues, recommendations and ideas. The reader will locate many examples of this. Muller's as soon as well-known after which nearly forgotten class of genes via their motion has now been given biochemical truth through reports of gene motion in vitro. the matter of no matter if mutations can come up in non-replicating genomes is likely one of the oldest in mutation study; but an unequivocal resolution was once bought only in the near past with bacteriophage.

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Additional resources for Mutation research: Problems, results and perspectives

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Deletions for single genes may sometimes be recognized by the fact that the heterozygote for a recessive gene is more extreme in phenotype than the homozygote for the same gene. We shall come back to this 'exaggeration effect' in the next chapter. The specific locus test is a well-known method for scoring visible mutations, including small deletions, in diploid organisms. It consists of crossing treated wild-type individuals with untreated ones that are homozygous for a number of recessive visible mutations.

14 Mutation research 18. Novick,A. (l950), 'Description of the Chemostat', Science 112, 715-716. 19. 'Genes and chromosomes, structure and organization', (1941), Cold Spring Harbor Symp. Quant. Bioi. 9. 20. 'Genes and Mutations' (1951), Cold Spring Harbor Symp. Quant. Bioi. 16. 21. Henning, U. and Yanofsky C. (1962), 'Amino acid replacements associated with reversion and recombination within the A gene',Proc. Nat. Acad. Sci. A. 18,1497-1504. 22. M. G. (1970), 'The intercistronic divide: Translation of an intercistronic region in the histidine operon of Salmonella typhimurium', Nature 226, 908-911.

B) The two centromere-proximal fragments join, yielding a dicentric, and the two centromere-distal fragments join, yielding an acentric fragment. The latter gets lost, while the former is drawn out into a bridge between opposite spindle poles at anaphase. If the bridge persists, it prevents separation of the chromosomes at telophase and so stops development. If it breaks under tension, it results in two daughter cells with broken chromosomes and these, in turn, carry out a 'breakage-fusion-bridge' cycle.

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