By Michael J. Gonzalez
Research on diet C and its results on melanoma is transforming into in reputation world wide as optimistic study keeps to acquire development a much better case for its effectiveness. This concise SpringerBrief on diet C and melanoma provides the newest findings on how diet C induces apoptosis. A excessive focus of diet C enables ascorbate to generate hydrogen peroxide in tissue which can selectively kill melanoma cells. study has proven that high-dose diet C is cytotoxic to a large choice of melanoma phone strains, and that it additionally boosts the anti-cancer job of a number of universal chemotherapy medications. nutrition C additionally does greater than simply kill melanoma cells. It boosts immunity by means of stimulating collagen formation to aid the physique wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade different organs in the course of the physique. This concise and updated short is geared in the direction of melanoma researchers and scientists, in addition to physicians drawn to the elemental technological know-how and the translational strength of diet C in melanoma therapeutics.
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Extra info for New Insights on Vitamin C and Cancer
Clinical and experimental experiences with intravenous vitamin C. J Orthomolec Med. 2000;15:201–13. 81. Casciari JJ, Riordan NH, Schmidt TL, Meng XL, Jackson JA, Riordan HD. Cytotoxicity of ascorbate, lipoic acid and other antioxidants in hollow ﬁber in vitro tumours. Brit J Cancer. 2001;84:1544–50. 82. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age associated decline in ascorbic acid concentration, recycling and biosynthesis in rat hepatocytes-reversal with (R)-α-lipoic acid supplementation.
1–23 μM) concentrations. Low plasma vitamin C concentrations were associated with shorter survival . The Antioxidant and Chemotherapy Debate in Cancer Treatment: The Modern Controversy Vitamin C in cancer therapy stirs controversy. But the focus is not only on whether vitamin C brings a survival edge, but whether it enhances or undermines standard cancer therapies. There has been a concern that antioxidants might reduce the effectiveness of chemotherapy and radiation by reducing the potency of free radicals necessary for cell killing.
A most unusual characteristic was the pronounced sensitivity of the cells to ascorbic acid. Concentrations down to 50 umol/L killed the cells within hours . Summary of antineoplastic and vitamin C in vitro studies: 1. Cell types. In vitro testing included a variety of human and mouse cell lines of including neuroblastoma, non-small cell cancer, cervical carcinoma, lymphoma, esophageal, breast, pancreatic, prostate, colon, and pleural. 2. Antineoplastic evaluated. Included radiation, 5-FU, bleomycin, methotrexate dacarbazine vincristine doxorubicin, paclitaxel, cisplatin, etoposide, gemcitabine, taxel, epirubicin, irinotecan, oxaliplatin, and vinorelbine.